Castle Bravo was the first in a series of high-yield thermonuclear weapon design tests conducted by the United States at Bikini Atoll, Marshall Islands, as part of Operation Castle. Detonated on March 1, 1954, the device was the most powerful nuclear device detonated by the United States and its first lithium deuteride fueled thermonuclear weapon. Castle Bravo's yield was 15 megatonnes of TNT (63 PJ), 2.5 times the predicted 6 megatonnes of TNT (25 PJ), due to unforeseen additional reactions involving lithium-7, which led to the unexpected radioactive contamination of areas to the east of Bikini Atoll. At the time, it was the most powerful artificial explosion in history.

Fallout, the heaviest of which was in the form of pulverized surface coral from the detonation, fell on residents of Rongelap and Utirik atolls, while the more particulate and gaseous fallout spread around the world. The inhabitants of the islands were not evacuated until three days later and suffered radiation sickness. Twenty-three crew members of the Japanese fishing vessel Daigo Fukury Maru ("Lucky Dragon No. 5") were also contaminated by the heavy fallout, experiencing acute radiation syndrome. The blast incited international reaction over atmospheric thermonuclear testing.The Bravo Crater is located at 114150N 1651619E. The remains of the Castle Bravo causeway are at 11426N 165177E.

Nuclear weapons tests are experiments carried out to determine nuclear weapons' effectiveness, yield, and explosive capability. Testing nuclear weapons offers practical information about how the weapons function, how detonations are affected by different conditions, and how personnel, structures, and equipment are affected when subjected to nuclear explosions. However, nuclear testing has often been used as an indicator of scientific and military strength. Many tests have been overtly political in their intention; most nuclear weapons states publicly declared their nuclear status through a nuclear test.

The first nuclear device was detonated as a test by the United States at the Trinity site in New Mexico on July 16, 1945, with a yield approximately equivalent to 20 kilotons of TNT. The first thermonuclear weapon technology test of an engineered device, codenamed "Ivy Mike", was tested at the Enewetak Atoll in the Marshall Islands on November 1, 1952 (local date), also by the United States. The largest nuclear weapon ever tested was the "Tsar Bomba" of the Soviet Union at Novaya Zemlya on October 30, 1961, with the largest yield ever seen, an estimated 50–58 megatons.

In 1963, three (UK, US, Soviet Union) of the then four nuclear states and many non-nuclear states signed the Limited Test Ban Treaty, pledging to refrain from testing nuclear weapons in the atmosphere, underwater, or in outer space. The treaty permitted underground nuclear testing. France continued atmospheric testing until 1974, and China continued until 1980. Neither has signed the treaty.Underground tests in the Soviet Union continued until 1990, the United Kingdom until 1991, the United States until 1992 (its last nuclear test), and both China and France until 1996. In signing the Comprehensive Nuclear-Test-Ban Treaty in 1996, these countries have pledged to discontinue all nuclear testing; the treaty has not yet entered into force because of failure to be ratified by eight countries. Non-signatories India and Pakistan last tested nuclear weapons in 1998. North Korea conducted nuclear tests in 2006, 2009, 2013, 2016, and 2017. The most recent confirmed nuclear test occurred in September 2017 in North Korea.