Pope John XXII (Latin: Ioannes PP. XXII; 1244 – 4 December 1334), born Jacques Duèze (or d'Euse), was head of the Catholic Church from 7 August 1316 to his death in 1334.

He was the second and longest-reigning Avignon Pope, elected by the Conclave of Cardinals, which was assembled in Lyon through the work of King Louis X's brother Philip, the Count of Poitiers, later King Philip V of France. Like his predecessor, Clement V, Pope John centralized power and income in the Papacy and lived a princely life in Avignon. He opposed the political policies of Louis IV of Bavaria as Holy Roman Emperor, which prompted Louis to invade Italy and set up an antipope, Nicholas V.

Pope John XXII faced controversy in theology involving his views on the beatific vision, and he opposed the Franciscan understanding of the poverty of Christ and his apostles, famously leading William of Ockham to write against unlimited papal power. In 1323, he canonized Thomas Aquinas.