Jesse Jefferson, American baseball player (d. 2011)
Jesse Harrison Jefferson (March 3, 1949 – September 8, 2011) was an American professional baseball pitcher with the Baltimore Orioles (1973-1975), Chicago White Sox (1975-1976), Toronto Blue Jays (1977-1980), Pittsburgh Pirates (1980) and California Angels (1981) of Major League Baseball (MLB). Jefferson batted left-handed and threw right-handed.