The Kingdom of the Two Sicilies (Neapolitan: Regno d''e Ddoje Sicilie; Sicilian: Regnu dî Dui Sicili; Italian: Regno delle Due Sicilie; Spanish: Reino de las Dos Sicilias) was a kingdom in Southern Italy from 1816 to 1860. The kingdom was the largest sovereign state by population and size in Italy before Italian unification, comprising Sicily and all of the Italian Peninsula south of the Papal States, which covered most of the area of today's Mezzogiorno.

The kingdom was formed when the Kingdom of Sicily merged with the Kingdom of Naples, which was officially also known as the Kingdom of Sicily. Since both kingdoms were named Sicily, they were collectively known as the "Two Sicilies" (Utraque Sicilia, literally "both Sicilies"), and the unified kingdom adopted this name. The king of the Two Sicilies was overthrown by Giuseppe Garibaldi in 1860, after which the people voted in a plebiscite to join the Savoyard Kingdom of Sardinia. The annexation of the Kingdom of the Two Sicilies completed the first phase of Italian unification, and the new Kingdom of Italy was proclaimed in 1861.

The Two Sicilies were heavily agricultural, like the other Italian states.