Virginia de' Medici, Italian princess (d. 1615)
Virginia de' Medici (29 May 1568 – 15 January 1615) was an Italian princess, a member of the House of Medici and by marriage Duchess of Modena and Reggio.

Regent of the Duchy of Modena and Reggio in 1601 during the absence of her husband, she was able to protect the autonomy of the city of Modena from the attacks of the local Podestà and Judge. Her husband's infidelities increased her already erratic behavior and led to a permanent mental illness, which lasted until her death.