Mercury-Redstone 3, or Freedom 7, was the first United States human spaceflight, on May 5, 1961, piloted by astronaut Alan Shepard. It was the first crewed flight of Project Mercury. The project had the ultimate objective of putting an astronaut into orbit around the Earth and return him safely. Shepard's mission was a 15-minute suborbital flight with the primary objective of demonstrating his ability to withstand the high g-forces of launch and atmospheric re-entry.

Shepard named his space capsule Freedom 7, setting a precedent for the remaining six Mercury astronauts naming their spacecraft. The number 7 was included in all the crewed Mercury spacecraft names to honor NASA's first group of seven astronauts. His spacecraft reached an altitude of 101.2 nautical miles (116.5 statute miles, 187.5 km) and traveled a downrange distance of 263.1 nautical miles (302.8 statute miles, 487.3 km). It was the fourth Mercury flight launched with the Mercury-Redstone Launch Vehicle, from Cape Canaveral, Florida, close to the Atlantic Ocean.

During the flight, Shepard observed the Earth and tested the capsule's attitude control system, turning the capsule around to face its blunt heat shield forward for atmospheric re-entry. He also tested the retrorockets which would return later missions from orbit, though the capsule did not have enough energy to remain in orbit. After re-entry, the capsule landed by parachute on the North Atlantic Ocean off the Bahamas. Shepard and the capsule were picked up by helicopter and brought to U.S. Navy aircraft carrier USS Lake Champlain.

The mission was a technical success, though American pride in the accomplishment was dampened by the fact that just three weeks before, the Soviet Union had launched the first human in space, Yuri Gagarin, who completed one orbit on Vostok 1 (but was controversial in that Gagarin had violated FAI rules that stated the pilot had to remain in the spacecraft, as he had ejected prior to landing, in violation of FAI rules ). In 2017 the first National Astronaut Day was held on May 5 to pay tribute to this first U.S. flight.

Project Mercury was the first human spaceflight program of the United States, running from 1958 through 1963. An early highlight of the Space Race, its goal was to put a man into Earth orbit and return him safely, ideally before the Soviet Union. Taken over from the US Air Force by the newly created civilian space agency NASA, it conducted 20 uncrewed developmental flights (some using animals), and six successful flights by astronauts. The program, which took its name from Roman mythology, cost $2.27 billion (adjusted for inflation). The astronauts were collectively known as the "Mercury Seven", and each spacecraft was given a name ending with a "7" by its pilot.

The Space Race began with the 1957 launch of the Soviet satellite Sputnik 1. This came as a shock to the American public, and led to the creation of NASA to expedite existing US space exploration efforts, and place most of them under civilian control. After the successful launch of the Explorer 1 satellite in 1958, crewed spaceflight became the next goal. The Soviet Union put the first human, cosmonaut Yuri Gagarin, into a single orbit aboard Vostok 1 on April 12, 1961. Shortly after this, on May 5, the US launched its first astronaut, Alan Shepard, on a suborbital flight. Soviet Gherman Titov followed with a day-long orbital flight in August 1961. The US reached its orbital goal on February 20, 1962, when John Glenn made three orbits around the Earth. When Mercury ended in May 1963, both nations had sent six people into space, but the Soviets led the US in total time spent in space.

The Mercury space capsule was produced by McDonnell Aircraft, and carried supplies of water, food and oxygen for about one day in a pressurized cabin. Mercury flights were launched from Cape Canaveral Air Force Station in Florida, on launch vehicles modified from the Redstone and Atlas D missiles. The capsule was fitted with a launch escape rocket to carry it safely away from the launch vehicle in case of a failure. The flight was designed to be controlled from the ground via the Manned Space Flight Network, a system of tracking and communications stations; back-up controls were outfitted on board. Small retrorockets were used to bring the spacecraft out of its orbit, after which an ablative heat shield protected it from the heat of atmospheric reentry. Finally, a parachute slowed the craft for a water landing. Both astronaut and capsule were recovered by helicopters deployed from a US Navy ship.

The Mercury project gained popularity, and its missions were followed by millions on radio and TV around the world. Its success laid the groundwork for Project Gemini, which carried two astronauts in each capsule and perfected space docking maneuvers essential for crewed lunar landings in the subsequent Apollo program announced a few weeks after the first crewed Mercury flight.