Michelangelo di Lodovico Buonarroti Simoni (Italian: [mikelandelo di lodoviko bwnarrti simoni]; 6 March 1475 18 February 1564), known simply as Michelangelo (English: ), was an Italian sculptor, painter, architect and poet of the High Renaissance. Born in the Republic of Florence, his work had a major influence on the development of Western art, particularly in relation to the Renaissance notions of humanism and naturalism. He is often considered a contender for the title of the archetypal Renaissance man, along with his rival and elder contemporary, Leonardo da Vinci. Given the sheer volume of surviving correspondence, sketches, and reminiscences, Michelangelo is one of the best-documented artists of the 16th century and several scholars have described Michelangelo as the most accomplished artist of his era.He sculpted two of his best-known works, the Piet and David, before the age of thirty. Despite holding a low opinion of painting, he also created two of the most influential frescoes in the history of Western art: the scenes from Genesis on the ceiling of the Sistine Chapel in Rome, and The Last Judgment on its altar wall. His design of the Laurentian Library pioneered Mannerist architecture. At the age of 71, he succeeded Antonio da Sangallo the Younger as the architect of St. Peter's Basilica. He transformed the plan so that the western end was finished to his design, as was the dome, with some modification, after his death.

Michelangelo was the first Western artist whose biography was published while he was alive. In fact, two biographies were published during his lifetime. One of them, by Giorgio Vasari, proposed that Michelangelo's work transcended that of any artist living or dead, and was "supreme in not one art alone but in all three."In his lifetime, Michelangelo was often called Il Divino ("the divine one"). His contemporaries often admired his terribilithis ability to instil a sense of awe in viewers of his art. Attempts by subsequent artists to imitate Michelangelo's impassioned, highly personal style contributed to the rise of Mannerism, a short-lived style and period in Western art following the High Renaissance.

The Sistine Chapel (; Latin: Sacellum Sixtinum; Italian: Cappella Sistina [kapˈpɛlla siˈstiːna]) is a chapel in the Apostolic Palace, in Vatican City and the official residence of the pope. Originally known as the Cappella Magna ('Great Chapel'), the chapel takes its name from Pope Sixtus IV, who had it built between 1473 and 1481. Since that time, the chapel has served as a place of both religious and functionary papal activity. Today, it is the site of the papal conclave, the process by which a new pope is selected. The fame of the Sistine Chapel lies mainly in the frescoes that decorate the interior, most particularly the Sistine Chapel ceiling and The Last Judgment, both by Michelangelo.

During the reign of Sixtus IV, a team of Renaissance painters that included Sandro Botticelli, Pietro Perugino, Pinturicchio, Domenico Ghirlandaio and Cosimo Rosselli, created a series of frescos depicting the Life of Moses and the Life of Christ, offset by papal portraits above and trompe-l'œil drapery below. These paintings were completed in 1482, and on 15 August 1483 Sixtus IV celebrated the first mass in the Sistine Chapel for the Feast of the Assumption, at which ceremony the chapel was consecrated and dedicated to the Virgin Mary.Between 1508 and 1512, under the patronage of Pope Julius II, Michelangelo painted the chapel's ceiling, a project which changed the course of Western art and is regarded as one of the major artistic accomplishments of human civilization. In a different political climate, after the Sack of Rome, he returned and, between 1535 and 1541, painted The Last Judgment for Popes Clement VII and Paul III. The fame of Michelangelo's paintings has drawn multitudes of visitors to the chapel ever since they were revealed five hundred years ago.