Afzal Khan, Indian commander
Afzal Khan (died 20 November 1659) was a general who served the Adil Shahi dynasty of Bijapur Sultanate in India. He played an important role in the southern expansion of the Bijapur Sultanate by subjugating the Nayaka chiefs who had taken control of the former Vijayanagara territory.

In 1659, the Bijapur government sent Afzal Khan to subjugate Shivaji, a former vassal who had started acting independently. He was killed at a truce negotiation meeting with Shivaji, and his army was defeated at the Battle of Pratapgad.