The Farmington Mine disaster was an explosion that happened at approximately 5:30 a.m. on November 20, 1968, at the Consol No. 9 coal mine north of Farmington and Mannington, West Virginia, United States.

The explosion was large enough to be felt in Fairmont, almost 12 miles away. At the time, 99 miners were inside. Over the course of the next few hours, 21 miners were able to escape the mine, but 78 were still trapped. All who were unable to escape perished; the bodies of 19 of the dead were never recovered. The cause of the explosion was never determined, but the accident served as the catalyst for several new laws that were passed to protect miners.