The 2012 Tel Aviv bus bombing was a mass-injury terror attack carried out on November 21, 2012, on a crowded passenger bus driving in the center of Tel Aviv's business district. The attack was carried out by an Israeli citizen of Arab descent, who remotely detonated an explosive device, which he had hid on the bus in advance. Twenty-eight civilians were injured in the attack, among them three who were injured seriously. The attack was carried out on the 8th and last day of Operation Pillar of Defense, only a few hours before the ceasefire was reached.

The attack was the first mass-injury terror attack in Tel Aviv since the 2006 Tel Aviv shawarma restaurant bombing, in which 11 people were killed and 70 were injured.