The MGM Grand fire occurred on Friday, November 21, 1980 at the MGM Grand Hotel and Casino (now Bally's Las Vegas), located on the Las Vegas Strip in Paradise, Nevada. The fire killed 85 people, most through smoke inhalation. The fire began from a refrigerated pastry display case in one of the restaurants, located on the first floor. Fire engulfed the resort's casino, and smoke travelled into the hotel tower.

The tragedy remains the deadliest disaster in Nevada history, and the third-deadliest hotel fire in modern U.S. history, after the 1946 Winecoff Hotel fire in Atlanta that killed 119 people and the 1986 Dupont Plaza Hotel fire in Puerto Rico that killed 97. The incident led to the reformation of fire safety guidelines and codes in the state.