John F. Kennedy, the 35th president of the United States, was assassinated on Friday, November 22, 1963, at 12:30 p.m. CST in Dallas, Texas, while riding in a presidential motorcade through Dealey Plaza. Kennedy was in the vehicle with his wife Jacqueline, Texas Governor John Connally, and Connally's wife Nellie when he was fatally shot from the nearby Texas School Book Depository by Lee Harvey Oswald, a former US Marine. Governor Connally was seriously wounded in the attack. The motorcade rushed to Parkland Memorial Hospital, where Kennedy was pronounced dead about 30 minutes after the shooting; Connally recovered.

About 70 minutes after Kennedy and Connally were shot, Oswald was arrested by the Dallas Police Department and charged under Texas state law with the murders of Kennedy and of J. D. Tippit, a Dallas police officer. At 11:21 a.m. on November 24, 1963, as live television cameras covered Oswald being moved through the basement of Dallas Police Headquarters, he was fatally shot by Dallas nightclub operator Jack Ruby. Like Kennedy, Oswald was also taken to Parkland Memorial Hospital, where he soon died. Ruby was convicted of Oswald's murder, though it was later overturned on appeal, and Ruby died in prison in 1967 while awaiting a new trial.

After a 10-month investigation, the Warren Commission concluded that Oswald assassinated Kennedy, that Oswald had acted entirely alone, and that Ruby had acted alone in killing Oswald. Kennedy was the eighth and most recent US president to die in office, and the fourth (following Lincoln, Garfield, and McKinley) to be assassinated. Vice President Lyndon B. Johnson automatically became president upon Kennedy's death.In its 1979 report, the United States House Select Committee on Assassinations (HSCA) agreed with the Warren Commission that Oswald's three rifle shots caused the injuries that Kennedy and Connally sustained. After analysis of a dictabelt audio recording the HSCA concluded that Kennedy was likely "assassinated as a result of a conspiracy". The committee could not identify a second gunman or group involved in the possible conspiracy, although the HSCA concluded that analysis pointed to the existence of an additional gunshot and "a high probability that two gunmen fired at [the] President".The U.S. Justice Department concluded active investigations and stated "that no persuasive evidence can be identified to support the theory of a conspiracy" in the assassination. However, Kennedy's assassination is still the subject of widespread debate and has spawned numerous conspiracy theories and alternative scenarios. Polls conducted from 1966 to 2004 found that up to 80 percent of Americans suspected that there was a plot or cover-up. The assassination was the first of four major assassinations of the 1960s in the United States, coming two years before the assassination of Malcolm X in 1965, and five years before the assassinations of Martin Luther King Jr. and Robert F. Kennedy in 1968.

John Fitzgerald Kennedy (May 29, 1917 – November 22, 1963), often referred to by his initials JFK, was an American politician who served as the 35th president of the United States from 1961 until his assassination near the end of his third year in office. Kennedy served at the height of the Cold War, and the majority of his work as president concerned relations with the Soviet Union and Cuba. A Democrat, he represented Massachusetts in both houses of the U.S. Congress prior to his presidency.

Born into the prominent Kennedy family in Brookline, Massachusetts, Kennedy graduated from Harvard University in 1940 before joining the U.S. Naval Reserve the following year. During World War II, he commanded a series of PT boats in the Pacific theater. Kennedy's survival of the sinking of PT-109 and rescue of his fellow sailors made him a war hero for which he earned the Navy and Marine Corps Medal, but left him with serious injuries. After a brief stint in journalism, Kennedy represented a working-class Boston district in the U.S. House of Representatives from 1947 to 1953. He was subsequently elected to the U.S. Senate and served as the junior senator for Massachusetts from 1953 to 1960. While in the Senate, Kennedy published his book, Profiles in Courage, which won a Pulitzer Prize. In the 1960 presidential election, he narrowly defeated Republican opponent Richard Nixon, who was the incumbent vice president. Kennedy's humor, charm, and youth in addition to his father's money and contacts were great assets in his campaign. Kennedy's campaign gained momentum after the first televised presidential debates in American history. He was the first Catholic elected president.

Kennedy's administration included high tensions with communist states in the Cold War. As a result, he increased the number of American military advisers in South Vietnam. The Strategic Hamlet Program began in Vietnam during his presidency. In April 1961, he authorized an attempt to overthrow the Cuban government of Fidel Castro in the failed Bay of Pigs Invasion. Kennedy authorized the Cuban Project in November 1961. He rejected Operation Northwoods (plans for false flag attacks to gain approval for a war against Cuba) in March 1962. However, his administration continued to plan for an invasion of Cuba in the summer of 1962. The following October, US spy planes discovered Soviet missile bases had been deployed in Cuba; the resulting period of tensions, termed the Cuban Missile Crisis, nearly resulted in the breakout of a global thermonuclear conflict. He also signed the first nuclear weapons treaty in October 1963. Kennedy presided over the establishment of the Peace Corps, Alliance for Progress with Latin America, and the continuation of the Apollo program with the goal of landing a man on the Moon before 1970. He also supported the civil rights movement, but was only somewhat successful in passing his New Frontier domestic policies.

On November 22, 1963, he was assassinated in Dallas. Vice President Lyndon B. Johnson assumed the presidency upon Kennedy's death. Marxist and former U.S. Marine Lee Harvey Oswald was arrested for the assassination, but he was shot and killed by Jack Ruby two days later. The FBI and the Warren Commission both concluded Oswald had acted alone. After Kennedy's death, Congress enacted many of his proposals, including the Civil Rights Act and the Revenue Act of 1964. Despite his truncated presidency, Kennedy ranks highly in polls of U.S. presidents with historians and the general public. His personal life has also been the focus of considerable sustained interest following public revelations in the 1970s of his chronic health ailments and extramarital affairs. Kennedy is the most recent U.S. president to have been assassinated as well as the most recent U.S. president to die in office.