Flavius Rufinus (Greek: Φλάβιος Ῥουφῖνος; c. 335 – 27 November 395) was a 4th-century East Roman statesman of Aquitanian extraction who served as Praetorian prefect of the East for the emperor Theodosius I, as well as for his son Arcadius, under whom Rufinus exercised significant influence in the state affairs.

He was the subject of the verse invective In Rufinum by the western court poet Claudian.