Choh Hao Li, Chinese-American biologist and chemist (b. 1913)
Choh Hao Li (sometimes Cho Hao Li) (Chinese: 李卓皓; pinyin: Lǐ Zhuōhào; April 21, 1913 – November 28, 1987) was a Chinese-born American biochemist who discovered, in 1966, that human pituitary growth hormone (somatotropin) consists of a chain of 256 amino acids. In 1970 he succeeded in synthesizing this hormone, the largest protein molecule synthesized up to that time.
Li was born in Guangzhou and educated at the Nanjing University. In 1935 he immigrated to the US, where he took up postgraduate studies at the University of California, Berkeley and later joined the staff. He became professor in 1950. He served as Director of the Hormone Research Laboratory at Berkeley from 1950 to 1967 and at UCSF from 1967 until his retirement in 1983. In 1955 he was elected as Academician of Academia Sinica, Republic of China.
Li spent his entire academic career studying the pituitary-gland hormones. In collaboration with various co-workers, he isolated several protein hormones, including adrenocorticotropic hormone (ACTH), which stimulates the adrenal cortex to increase its secretion of corticoids. In 1956, Li and his group showed that ACTH consists of 39 amino acids arranged in a specific order, and that the whole chain of the natural hormone is not necessary for its action. He isolated another pituitary hormone called melanocyte-stimulating hormone (MSH) and found that not only does this hormone produce some effects similar to those produced by ACTH, but also that part of the amino acid chain of MSH is the same as that of ACTH.
1987Nov, 28
Choh Hao Li
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Events on 1987
- 27Apr
Kurt Waldheim
The U.S. Department of Justice bars Austrian President Kurt Waldheim (and his wife, Elisabeth, who had also been a Nazi) from entering the USA, charging that he had aided in the deportations and executions of thousands of Jews and others as a German Army officer during World War II. - 1May
Auschwitz concentration camp
Pope John Paul II beatifies Edith Stein, a Jewish-born Carmelite nun who was gassed in the Nazi concentration camp at Auschwitz. - 5Jul
Liberation Tigers of Tamil Eelam
Sri Lankan Civil War: The LTTE uses suicide attacks on the Sri Lankan Army for the first time. The Black Tigers are born and, in the following years, will continue to kill with the tactic. - 27Jul
RMS Titanic
RMS Titanic Inc. begins the first expedited salvage of wreckage of the RMS Titanic. - 7Nov
Habib Bourguiba
In Tunisia, president Habib Bourguiba is overthrown and replaced by Prime Minister Zine El Abidine Ben Ali.