Gran Colombia (Spanish pronunciation: [a kolombja] (listen), "Great Colombia"), or Greater Colombia, officially the Republic of Colombia (Spanish: Repblica de Colombia), was a state that encompassed much of northern South America and part of southern Central America from 1819 to 1831. It included present-day Colombia, mainland Ecuador (i.e. excluding the Galpagos Islands), Panama, and Venezuela, along with parts of northern Peru, northwestern Brazil, and Essequibo, Guyana. The terms Gran Colombia and Greater Colombia are used historiographically to distinguish it from the current Republic of Colombia, which is also the official name of the former state.

But international recognition of the legitimacy of the Gran Colombian state ran afoul of European opposition to the independence of states in the Americas. Austria, France, and Russia only recognized independence in the Americas if the new states accepted monarchs from European dynasties. In addition, Colombia and the international powers disagreed over the extension of the Colombian territory and its boundaries.Gran Colombia was proclaimed through the Fundamental Law of the Republic of Colombia, issued during the Congress of Angostura (1819), but did not come into being until the Congress of Ccuta (1821) promulgated the Constitution of Ccuta.

Gran Colombia was constituted as a unitary centralist state. Its existence was marked by a struggle between those who supported a centralized government with a strong presidency and those who supported a decentralized, federal form of government. At the same time, another political division emerged between those who supported the Constitution of Ccuta and two groups who sought to do away with the Constitution, either in favor of breaking up the country into smaller republics or maintaining the union but creating an even stronger presidency. The faction that favored constitutional rule coalesced around Vice-President Francisco de Paula Santander, while those who supported the creation of a stronger presidency were led by President Simn Bolvar. The two of them had been allies in the war against Spanish rule, but by 1825, their differences had become public and were an important part of the political instability from that year onward.

Gran Colombia was dissolved in 1831 due to the political differences that existed between supporters of federalism and centralism, as well as regional tensions among the peoples that made up the republic. It broke into the successor states of Colombia, Ecuador, and Venezuela; Panama was separated from Colombia in 1903. Since Gran Colombia's territory corresponded more or less to the original jurisdiction of the former Viceroyalty of New Granada, it also claimed the Caribbean coast of Nicaragua, the Mosquito Coast, as well as most of Esequiba.

This article is about public holidays in Panama.