The Battle of Lost River in November 1872 was the first battle in the Modoc War in the northwestern United States. The skirmish, which was fought near the Lost River along the CaliforniaOregon border, was the result of an attempt by the U.S. 1st Cavalry Regiment of the United States Army to force a band of the Modoc tribe to relocate back to the Klamath Reservation, which they had left in objection of its conditions.

In the subsequent war, Captain Jack of the Modoc and 53 warriors held off more than 1000 U.S. soldiers for 7 months in the area of the present-day Lava Beds National Monument. Part of this was named Captain Jack's Stronghold in his honor.

The Modoc War, or the Modoc Campaign (also known as the Lava Beds War), was an armed conflict between the Native American Modoc people and the United States Army in northeastern California and southeastern Oregon from 1872 to 1873. Eadweard Muybridge photographed the early part of the US Army's campaign.

Kintpuash, also known as Captain Jack, led 52 warriors in a band of more than 150 Modoc people who left the Klamath Reservation. Occupying defensive positions throughout the lava beds south of Tule Lake (in present-day Lava Beds National Monument), those few warriors resisted for months the more numerous United States Army forces sent against them, which were reinforced with artillery. In April 1873 at a peace commission meeting, Captain Jack and others killed General Edward Canby and Rev. Eleazer Thomas, and wounded two others, mistakenly believing this would encourage the Americans to leave. The Modoc fled back to the lava beds. After U.S. forces were reinforced, some Modoc warriors surrendered and Captain Jack and the last of his band were captured. Jack and five warriors were tried for the murders of the two peace commissioners. Jack and three warriors were executed and two others sentenced to life in prison.

The remaining 153 Modoc of the band were sent to Indian Territory (pre-statehood Oklahoma), where they were held as prisoners of war until 1909, settled on reservation land with the Shawnee. Some at that point were allowed to return to the Klamath Reservation in Oregon. Most Modoc (and their descendants) stayed in what became the state of Oklahoma. They achieved separate federal recognition and were granted some land in Oklahoma. There are two federally recognized Modoc tribes: in Oregon and Oklahoma.