The Hanford Site is a decommissioned nuclear production complex operated by the United States federal government on the Columbia River in Benton County in the U.S. state of Washington. The site has been known by many names, including Hanford Project, Hanford Works, Hanford Engineer Works and Hanford Nuclear Reservation. Established in 1943 as part of the Manhattan Project, the site was home to the B Reactor, the first full-scale plutonium production reactor in the world. Plutonium manufactured at the site was used in the first atomic bomb, which was tested at the Trinity site, and in the Fat Man bomb that was detonated over Nagasaki, Japan.

During the Cold War, the project expanded to include nine nuclear reactors and five large plutonium processing complexes, which produced plutonium for most of the more than 60,000 weapons built for the U.S. nuclear arsenal. Nuclear technology developed rapidly during this period, and Hanford scientists produced major technological achievements. Many early safety procedures and waste disposal practices were inadequate, resulting in the release of significant amounts of radioactive materials into the air and the Columbia River.

The weapons production reactors were decommissioned at the end of the Cold War, and the Hanford Site became the focus of the nation's largest environmental cleanup. Besides the cleanup project, Hanford also hosts a commercial nuclear power plant, the Columbia Generating Station, and various centers for scientific research and development, such as the Pacific Northwest National Laboratory, the Fast Flux Test Facility and the LIGO Hanford Observatory. In 2015 it was designated as part of the Manhattan Project National Historical Park.

Plutonium is a radioactive chemical element with the symbol Pu and atomic number 94. It is an actinide metal of silvery-gray appearance that tarnishes when exposed to air, and forms a dull coating when oxidized. The element normally exhibits six allotropes and four oxidation states. It reacts with carbon, halogens, nitrogen, silicon, and hydrogen. When exposed to moist air, it forms oxides and hydrides that can expand the sample up to 70% in volume, which in turn flake off as a powder that is pyrophoric. It is radioactive and can accumulate in bones, which makes the handling of plutonium dangerous.

Plutonium was first synthetically produced and isolated in late 1940 and early 1941, by a deuteron bombardment of uranium-238 in the 1.5-metre (60 in) cyclotron at the University of California, Berkeley. First, neptunium-238 (half-life 2.1 days) was synthesized, which subsequently beta-decayed to form the new element with atomic number 94 and atomic weight 238 (half-life 88 years). Since uranium had been named after the planet Uranus and neptunium after the planet Neptune, element 94 was named after Pluto, which at the time was considered to be a planet as well. Wartime secrecy prevented the University of California team from publishing its discovery until 1948.

Plutonium is the element with the highest atomic number to occur in nature. Trace quantities arise in natural uranium-238 deposits when uranium-238 captures neutrons emitted by decay of other uranium-238 atoms.

Both plutonium-239 and plutonium-241 are fissile, meaning that they can sustain a nuclear chain reaction, leading to applications in nuclear weapons and nuclear reactors. Plutonium-240 exhibits a high rate of spontaneous fission, raising the neutron flux of any sample containing it. The presence of plutonium-240 limits a plutonium sample's usability for weapons or its quality as reactor fuel, and the percentage of plutonium-240 determines its grade (weapons-grade, fuel-grade, or reactor-grade). Plutonium-238 has a half-life of 87.7 years and emits alpha particles. It is a heat source in radioisotope thermoelectric generators, which are used to power some spacecraft. Plutonium isotopes are expensive and inconvenient to separate, so particular isotopes are usually manufactured in specialized reactors.

Producing plutonium in useful quantities for the first time was a major part of the Manhattan Project during World War II that developed the first atomic bombs. The Fat Man bombs used in the Trinity nuclear test in July 1945, and in the bombing of Nagasaki in August 1945, had plutonium cores. Human radiation experiments studying plutonium were conducted without informed consent, and several criticality accidents, some lethal, occurred after the war. Disposal of plutonium waste from nuclear power plants and dismantled nuclear weapons built during the Cold War is a nuclear-proliferation and environmental concern. Other sources of plutonium in the environment are fallout from numerous above-ground nuclear tests, now banned.