Spiro Theodore Agnew (November 9, 1918 September 17, 1996) was the 39th vice president of the United States, serving from 1969 until his resignation in 1973. He is the second vice president to resign the position, the other being John C. Calhoun in 1832.

Agnew was born in Baltimore to a Greek immigrant father and an American mother. He attended Johns Hopkins University and graduated from the University of Baltimore School of Law. He worked as an aide to U.S. Representative James Devereux before he was appointed to the Baltimore County Board of Zoning Appeals in 1957. In 1962, he was elected Baltimore County Executive. In 1966, Agnew was elected Governor of Maryland, defeating his Democratic opponent George P. Mahoney and independent candidate Hyman A. Pressman.

At the 1968 Republican National Convention, Richard Nixon asked Agnew to place his name in nomination, and named him as running mate. Agnew's centrist reputation interested Nixon; the law and order stance he had taken in the wake of civil unrest that year appealed to aides such as Pat Buchanan. Agnew made a number of gaffes during the campaign, but his rhetoric pleased many Republicans, and he may have made the difference in several key states. Nixon and Agnew defeated the Democratic ticket of incumbent Vice President Hubert Humphrey and his running mate, Senator Edmund Muskie. As vice president, Agnew was often called upon to attack the administration's enemies. In the years of his vice presidency, Agnew moved to the right, appealing to conservatives who were suspicious of moderate stances taken by Nixon. In the presidential election of 1972, Nixon and Agnew were re-elected for a second term, defeating Senator George McGovern and his running mate Sargent Shriver in one of the largest landslides in American history.

In 1973, Agnew was investigated by the United States Attorney for the District of Maryland on suspicion of criminal conspiracy, bribery, extortion and tax fraud. Agnew took kickbacks from contractors during his time as Baltimore County Executive and Governor of Maryland. The payments had continued into his time as vice president; they had nothing to do with the Watergate scandal, in which he was not implicated. After months of maintaining his innocence, Agnew pleaded no contest to a single felony charge of tax evasion and resigned from office. Nixon replaced him with House Republican leader Gerald Ford. Agnew spent the remainder of his life quietly, rarely making public appearances. He wrote a novel and a memoir; both defended his actions. Agnew died at his home of undiagnosed acute leukemia.

The vice president of the United States (VPOTUS) is the second-highest officer in the executive branch of the U.S. federal government, after the president of the United States, and ranks first in the presidential line of succession. The vice president is also an officer in the legislative branch, as the president of the Senate. In this capacity, the vice president is empowered to preside over Senate deliberations at any time, but may not vote except to cast a tie-breaking vote. The vice president is indirectly elected together with the president to a four-year term of office by the people of the United States through the Electoral College.The modern vice presidency is a position of significant power and is widely seen as an integral part of a president's administration. While the exact nature of the role varies in each administration, most modern vice presidents serve as a key presidential advisor, governing partner, and representative of the president. The vice president is also a statutory member of the National Security Council and thus plays a significant role in national security matters. As the vice president's role within the executive branch has expanded, the legislative branch role has contracted; for example, vice presidents now preside over the Senate only infrequently.The role of the vice presidency has changed dramatically since the office was created during the 1787 Constitutional Convention. Originally something of an afterthought, the vice presidency was considered an insignificant office for much of the nation's history, especially after the Twelfth Amendment meant that vice presidents were no longer the runners-up in the presidential election. The vice president's role began steadily growing in importance during the 1930s, with the Office of the Vice President being created in the executive branch in 1939, and has since grown much further. Due to its increase in power and prestige, the vice presidency is now often considered to be a stepping stone to the presidency. Since the 1970s, the vice president has been afforded an official residence at Number One Observatory Circle.

The Constitution does not expressly assign the vice presidency to a branch of the government, causing a dispute among scholars about which branch the office belongs to (the executive, the legislative, both, or neither). The modern view of the vice president as an officer of the executive branch—one isolated almost totally from the legislative branch—is due in large part to the assignment of executive authority to the vice president by either the president or Congress. Nevertheless, modern vice presidents have often previously served in Congress, and are often tasked with helping to advance an administration's legislative priorities.

Kamala Harris is the 49th and current vice president of the United States. She is the first African American, first Asian American, and first female occupant of the office. She assumed office on January 20, 2021.