The Sack of Wexford took place from 2 to 11 October 1649, during the campaign known as the Cromwellian conquest of Ireland. It was part of the wider 1641 to 1653 Irish Confederate Wars, and an associated conflict of the Wars of the Three Kingdoms.

A Parliamentarian force under Oliver Cromwell stormed the town after negotiations broke down, killing most of the garrison. Many civilians also died, either during the sack, or drowned attempting to escape across the River Slaney. Along with Drogheda, Wexford is still remembered as an infamous atrocity.