Apollo 7 (October 11 22, 1968) was the first crewed flight in NASA's Apollo program, and saw the resumption of human spaceflight by the agency after the fire that killed the three Apollo 1 astronauts during a launch rehearsal test on January 27, 1967. The Apollo 7 crew was commanded by Walter M. Schirra, with command module pilot Donn F. Eisele and lunar module pilot R. Walter Cunningham (so designated even though Apollo 7 did not carry a Lunar Module).

The three astronauts were originally designated for the second crewed Apollo flight, and then as backups for Apollo 1. After the Apollo 1 fire, crewed flights were suspended while the cause of the accident was investigated and improvements made to the spacecraft and safety procedures, and uncrewed test flights made. Determined to prevent a repetition of the fire, the crew spent long periods of time monitoring the construction of their Apollo command and service modules (CSM). Training continued over much of the 21-month pause that followed the Apollo 1 disaster.

Apollo 7 was launched on October 11, 1968, from Cape Kennedy Air Force Station, Florida, and splashed down in the Atlantic Ocean eleven days later. Extensive testing of the CSM took place, and also the first live television broadcast from an American spacecraft. Despite tension between the crew and ground controllers, the mission was a complete technical success, giving NASA the confidence to send Apollo 8 into orbit around the Moon two months later. In part because of these tensions, none of the crew flew in space again, though Schirra had already announced he would retire from NASA after the flight. Apollo 7 fulfilled Apollo 1's mission of testing the CSM in low Earth orbit, and was a significant step towards NASA's goal of landing astronauts on the Moon.

The Apollo program, also known as Project Apollo, was the third United States human spaceflight program carried out by the National Aeronautics and Space Administration (NASA), which succeeded in preparing and landing the first humans on the Moon from 1968 to 1972. It was first conceived during Dwight D. Eisenhower's administration as a three-person spacecraft to follow the one-person Project Mercury, which put the first Americans in space. Apollo was later dedicated to President John F. Kennedy's national goal for the 1960s of "landing a man on the Moon and returning him safely to the Earth" in an address to Congress on May 25, 1961. It was the third US human spaceflight program to fly, preceded by the two-person Project Gemini conceived in 1961 to extend spaceflight capability in support of Apollo.

Kennedy's goal was accomplished on the Apollo 11 mission when astronauts Neil Armstrong and Buzz Aldrin landed their Apollo Lunar Module (LM) on July 20, 1969, and walked on the lunar surface, while Michael Collins remained in lunar orbit in the command and service module (CSM), and all three landed safely on Earth on July 24. Five subsequent Apollo missions also landed astronauts on the Moon, the last, Apollo 17, in December 1972. In these six spaceflights, twelve people walked on the Moon.

Apollo ran from 1961 to 1972, with the first crewed flight in 1968. It encountered a major setback in 1967 when an Apollo 1 cabin fire killed the entire crew during a prelaunch test. After the first successful landing, sufficient flight hardware remained for nine follow-on landings with a plan for extended lunar geological and astrophysical exploration. Budget cuts forced the cancellation of three of these. Five of the remaining six missions achieved successful landings, but the Apollo 13 landing was prevented by an oxygen tank explosion in transit to the Moon, which destroyed the service module's capability to provide electrical power, crippling the CSM's propulsion and life support systems. The crew returned to Earth safely by using the lunar module as a "lifeboat" for these functions. Apollo used the Saturn family of rockets as launch vehicles, which were also used for an Apollo Applications Program, which consisted of Skylab, a space station that supported three crewed missions in 1973–1974, and the Apollo–Soyuz Test Project, a joint United States-Soviet Union low Earth orbit mission in 1975.

Apollo set several major human spaceflight milestones. It stands alone in sending crewed missions beyond low Earth orbit. Apollo 8 was the first crewed spacecraft to orbit another celestial body, and Apollo 11 was the first crewed spacecraft to land humans on one.

Overall the Apollo program returned 842 pounds (382 kg) of lunar rocks and soil to Earth, greatly contributing to the understanding of the Moon's composition and geological history. The program laid the foundation for NASA's subsequent human spaceflight capability, and funded construction of its Johnson Space Center and Kennedy Space Center. Apollo also spurred advances in many areas of technology incidental to rocketry and human spaceflight, including avionics, telecommunications, and computers.