Andreas Michalakopoulos (Greek: Ανδρέας Μιχαλακόπουλος; 17 May 1876, in Patras – 7 March 1938, in Athens) was an important liberal politician in the inter-war period who served as Prime Minister of Greece from 7 October 1924 to 26 June 1925.

He was a senior member of the Liberal Party and a close associate of its founder, the Greek statesman Eleftherios Venizelos, for more than 20 years. With Venizelos he participated in the negotiations for the international treaties of Sèvres and Lausanne, and co-signed as Foreign Minister the Greek-Turkish Friendship Convention (also known as the Treaty of Ankara) on 30 October 1930.

He held important posts in several governments led by Eleftherios Venizelos, Alexandros Zaimis and Konstantinos Tsaldaris; Foreign Minister (1928–33), Minister for Economy (1912–916), Minister for Agriculture (1917–1918, 1920), Minister for Military Affairs (1918).

Opposed to the military dictatorship of Ioannis Metaxas, he was sent to political exile on Paros in 1936, which resulted in his death in 1938.He was buried in the First Cemetery of Athens.