Four laboratory-confirmed cases of Ebola virus disease (commonly known as "Ebola") occurred in the United States in 2014. Eleven cases were reported, including these four cases and seven cases medically evacuated from other countries. The first was reported in September 2014. Nine of the people contracted the disease outside the US and traveled into the country, either as regular airline passengers or as medical evacuees; of those nine, two died. Two people contracted Ebola in the United States. Both were nurses who treated an Ebola patient; both recovered.On September 30, 2014, the Centers for Disease Control and Prevention (CDC) announced that Thomas Eric Duncan, a reportedly 42-year-old (later corrected by CDC reports as a 45-year-old) Liberian national visiting the United States from Liberia, had been diagnosed with Ebola in Dallas, Texas.

Duncan, who had been visiting family in Dallas, was treated at Texas Health Presbyterian Hospital Dallas. By October 4, Duncan's condition had deteriorated from "serious but stable" to "critical". On October 8, Duncan died of Ebola. The other three cases diagnosed in the United States as of October 2014 were:

October 11, 2014, a nurse, Nina Pham, who had provided care to Duncan at the hospital.

October 14, 2014, Amber Joy Vinson, another nurse who treated Duncan.

October 23, 2014, physician Craig Spencer, diagnosed in New York City; he had just returned from working with Doctors Without Borders in Guinea, a country in West Africa. He was treated at Bellevue Hospital in New York City.Hundreds of people were tested or monitored for potential Ebola virus infection, but the two nurses were the only confirmed cases of locally transmitted Ebola. Public health experts and the Obama administration opposed instituting a travel ban on Ebola endemic areas, stating that it would be ineffective and would paradoxically worsen the situation.No one who contracted Ebola while in the United States died from it. No new cases were diagnosed in the United States after Spencer was released from Bellevue Hospital on November 11, 2014.

Thomas Eric Duncan (December 30, 1972 – October 8, 2014) was a Liberian citizen who became the first Ebola patient diagnosed in the United States on September 30, 2014.

Duncan, who had been visiting family in Dallas, was treated at Texas Health Presbyterian Hospital Dallas. By October 4, Duncan's condition had deteriorated from "serious but stable" to "critical". On October 8, Duncan died of Ebola. Two health care workers became infected with Ebola virus, 26-year-old nurse Nina Pham and 29-year-old nurse Amber Vinson, both of whom had taken care of him at Texas Health Presbyterian Hospital (THPH).

The family eventually threatened to sue the hospital based on the claim that Duncan had not received proper and timely care. The family was thus able to receive compensation from THPH. On November 10, 2014, Duncan's family reached a "resolution" with THPH that included the hospital covering the expenses related to Duncan's intensive and onerous treatment, as well as an undisclosed amount cash payment to the family.