Honduras was inhabited by many indigenous peoples when the Spanish arrived in the 16th century. The western-central part of Honduras was inhabited by the Lencas, the central north coast by the Tol, the area east and west of Trujillo by the Pech (or Paya), the Maya and Sumo. These autonomous groups maintained commercial relationships with each other and with other populations as distant as Panama and Mexico. Honduras has ruins of several cities dating from the Mesoamerican pre-classic period that show the pre-Columbian past of the country.

For the arrival of the Spanish, new cities were founded such as Trujillo, Comayagua, Gracias, and Tegucigalpa. Starting in the colonial era, the territory of what is today Honduras was dedicated to harvesting, mining, and ranching. After its independence from the Spanish Empire in 1821, Central America would join the first Mexican Empire for a very short time, which would fall in 1823 and the Central American federation would be created, which would fall in 1839. After that, the Honduran territory has become an independent nation.