Fort Manoel (Maltese: Forti Manoel or Fortizza Manoel) is a star fort on Manoel Island in Gira, Malta. It was built in the 18th century by the Order of Saint John, during the reign of Grand Master Antnio Manoel de Vilhena, after whom it is named. Fort Manoel is located to the north west of Valletta, and commands Marsamxett Harbour and the anchorage of Sliema Creek. The fort is an example of Baroque architecture, and it was designed with both functionality and aesthetics in mind.

After a brief French occupation which began in 1798, the British military took over the fort in 1800, and it remained in use by them until 1964. The fort was severely damaged in World War II, but it was restored in the early 21st century and it is now in good condition.

Fort Manoel has been on Malta's tentative list of UNESCO World Heritage Sites since 1998, as part of the Knights' Fortifications around the Harbours of Malta.

António Manoel de Vilhena (28 May 1663 – 10 December 1736) was a Portuguese nobleman who was the 66th Prince and Grand Master of the Order of St. John of Jerusalem from 19 June 1722 to his death in 1736. Unlike a number of the other Grand Masters, he was benevolent and popular with the Maltese people. Vilhena is mostly remembered for the founding of Floriana, the construction of Fort Manoel and the Manoel Theatre, and the renovation of the city of Mdina.