The Ford Piquette Avenue Plant is a former factory located within the Milwaukee Junction area of Detroit, Michigan, in the United States. Built in 1904, it was the second center of automobile production for the Ford Motor Company, after the Ford Mack Avenue Plant. At the Piquette Avenue Plant, the company created and first produced the Ford Model T, the car credited with initiating the mass use of automobiles in the United States. Prior to the Model T, several other car models were assembled at the factory. Early experiments using a moving assembly line to make cars were also conducted there. It was also the first factory where more than 100 cars were assembled in one day. While it was headquartered at the Piquette Avenue Plant, Ford Motor Company became the biggest U.S.-based automaker, and it would remain so until the mid-1920s. The factory was used by the company until 1910, when its car production activity was relocated to the new, bigger Highland Park Ford Plant.

Studebaker bought the factory in 1911, using it to assemble cars until 1933. The building was sold in 1936, going through a series of owners for the rest of the 20th century before becoming a museum in 2001. The Piquette Avenue Plant is the oldest purpose-built automotive factory building open to the public. The museum, which was visited by over 31,000 people in 2018, has exhibits that primarily focus on the beginning of the United States automotive industry. The building was added to the National Register of Historic Places in 2002, became a Michigan State Historic Site in 2003, and was designated a National Historic Landmark in 2006.

The Ford Model T is an automobile that was produced by Ford Motor Company from October 1, 1908, to May 26, 1927. It is generally regarded as the first affordable automobile, which made car travel available to middle-class Americans. The relatively low price was partly the result of Ford's efficient fabrication, including assembly line production instead of individual handcrafting. The Model T was colloquially known as the "Tin Lizzie," "Leaping Lena" or "flivver".The Ford Model T was named the most influential car of the 20th century in the 1999 Car of the Century competition, ahead of the BMC Mini, Citroën DS, and Volkswagen Beetle. Ford's Model T was successful not only because it provided inexpensive transportation on a massive scale, but also because the car signified innovation for the rising middle class and became a powerful symbol of the United States' age of modernization. With 15 million sold, it was the most sold car in history before being surpassed by the Volkswagen Beetle in 1972, and still stood eighth on the top-ten list, as of 2012.