The Mithridatic Wars were three conflicts fought by Rome against the Kingdom of Pontus and its allies between 88 BC and 63 BC. They are named after Mithridates VI, the King of Pontus who initiated the hostilities after annexing the Roman province of Asia into its Pontic Empire (that came to include most of Asia Minor) and committing massacres against the local Roman population known as the Asian Vespers. As Roman troops were sent to recover the territory, they faced an uprising in Greece organized and supported by Mithridates. Mithridates was able to mastermind such general revolts against Rome and played the magistrates of the optimates party off against the magistrates of the populares party in the Roman civil wars. Nevertheless, the first war ended with a Roman victory, confirmed by the Treaty of Dardanos signed by Sulla and Mithridates. Greece was restored to Roman rule and Pontus was expected to restore the status quo ante bellum in Asia Minor.

As the treaty of Dardanos was barely implemented in Asia Minor, the Roman general Murena (in charge of retaking control of Roman territory in Asia) decided to wage a second war against Pontus. The second war resulted in a Roman defeat and gave momentum to Mithridates, who then forged an alliance with Tigranes the Great, the Armenian King of Kings. Tigranes was the son-in-law of Mithridates and was in control of an Armenian empire that included territories in the Levant. Pontus won the Battle of Chalcedon (74 BC), gave support to Cilician pirates against Roman commerce, and the third war soon began.

For the third war, the Romans sent the consul Lucullus to fight against Armenia and Pontus. Lucullus won the Battle of Cabira and the Battle of Tigranocerta, but his progress was nullified after the Battle of Artaxata and the Battle of Zela. Meanwhile, the campaign of Pompey against the Cilician pirates in the Mediterranean was successful and Pompey was named by the Senate to replace Lucullus. Pompey's subsequent campaigns caused the collapse of the Armenian Empire in the Levant (with Roman forces taking control of Syria and Palestine) and the affirmation of Roman power over Anatolia, Pontus and nearly all the eastern Mediterranean. Tigranes surrendered and became a client king of Rome. Hunted, stripped of his possessions, and in a foreign country, Mithridates had a servant kill him. His former kingdom was combined with one of his hereditary enemies, Bithynia, to form the province of Bithynia and Pontus, which would forestall any future pretender to the throne of Pontus.

Gnaeus Pompeius Magnus (Latin: [ˈnːae̯.ʊs pɔmˈpɛjjʊs ˈmaŋnʊs]; 29 September 106 BC – 28 September 48 BC), known in English as Pompey or Pompey the Great, was a leading Roman general and statesman. He played a significant role in the transformation of Rome from republic to empire. He was (for a time) a student of Roman general Sulla as well as the political ally (and later enemy) of Julius Caesar.

A member of the senatorial nobility, Pompey entered into a military career while still young. He rose to prominence serving the dictator Sulla as a commander in the civil war of 83–82 BC. Pompey's success as a general while young enabled him to advance directly to his first Roman consulship without following the traditional cursus honorum (the required steps to advance in a political career). He was elected as Roman consul on three occasions. He celebrated three Roman triumphs, served as a commander in the Sertorian War, the Third Servile War, the Third Mithridatic War, and in various other military campaigns. Pompey's early success earned him the cognomen Magnus – "the Great" – after his boyhood hero Alexander the Great. His adversaries gave him the nickname adulescentulus carnifex ("teenage butcher") for his ruthlessness.In 60 BC, Pompey joined Crassus and Caesar in the military-political alliance known as the First Triumvirate. Pompey married Caesar's daughter, Julia, which helped secure this partnership. After the deaths of Crassus and Julia, Pompey became an ardent supporter of the political faction the optimates— a conservative faction of the Roman Senate. Pompey and Caesar then began contending for leadership of the Roman state in its entirety, eventually leading to Caesar's Civil War. Pompey was defeated at the Battle of Pharsalus in 48 BC, and he sought refuge in Ptolemaic Egypt, where he was assassinated in a plot by the courtiers of Ptolemy XIII.