The Maryland campaign (or Antietam campaign) occurred September 420, 1862, during the American Civil War. Confederate Gen. Robert E. Lee's first invasion of the North was repulsed by the Army of the Potomac under Maj. Gen. George B. McClellan, who moved to intercept Lee and his Army of Northern Virginia and eventually attacked it near Sharpsburg, Maryland. The resulting Battle of Antietam was the bloodiest single-day battle in American history.

Following his victory in the northern Virginia campaign, Lee moved north with 55,000 men through the Shenandoah Valley starting on September 4, 1862. His objective was to resupply his army outside of the war-torn Virginia theater and to damage Northern morale in anticipation of the November elections. He undertook the risky maneuver of splitting his army so that he could continue north into Maryland while simultaneously capturing the Federal garrison and arsenal at Harpers Ferry. McClellan accidentally found a copy of Lee's orders to his subordinate commanders and planned to isolate and defeat the separated portions of Lee's army.

While Confederate Maj. Gen. Stonewall Jackson surrounded, bombarded, and captured Harpers Ferry (September 1215), McClellan's army of 102,000 men attempted to move quickly through the South Mountain passes that separated him from Lee. The Battle of South Mountain on September 14 delayed McClellan's advance and allowed Lee sufficient time to concentrate most of his army at Sharpsburg. The Battle of Antietam (or Sharpsburg) on September 17 was the bloodiest day in American military history with over 22,000 casualties. Lee, outnumbered two to one, moved his defensive forces to parry each offensive blow, but McClellan never deployed all of the reserves of his army to capitalize on localized successes and destroy the Confederates. On September 18, Lee ordered a withdrawal across the Potomac and on September 1920, fights by Lee's rear guard at Shepherdstown ended the campaign.

Although Antietam was a tactical draw, it meant the strategy behind Lee's Maryland campaign had failed. President Abraham Lincoln used this Union victory as the justification for announcing his Emancipation Proclamation, which effectively ended any threat of European support for the Confederacy.

The American Civil War (April 12, 1861 – May 9, 1865; also known by other names) was a civil war in the United States between the Union (states that remained loyal to the federal union, or "the North") and the Confederacy (states that voted to secede, or "the South"). The central cause of the war was the status of slavery, especially the expansion of slavery into territories acquired as a result of the Louisiana Purchase and the Mexican–American War. On the eve of the Civil War in 1860, four million of the 32 million Americans (~13%) were enslaved black people, almost all in the South.The practice of slavery in the United States was one of the key political issues of the 19th century. Decades of political unrest over slavery led up to the Civil War. Disunion came after Abraham Lincoln won the 1860 United States presidential election on an anti-slavery expansion platform. An initial seven southern slave states declared their secession from the country to form the Confederacy. Confederate forces seized federal forts within territory they claimed. The last-minute Crittenden Compromise tried to avert conflict but failed; both sides prepared for war. Fighting broke out in April 1861 when the Confederate army began the Battle of Fort Sumter in South Carolina, just over a month after the first inauguration of Abraham Lincoln. The Confederacy grew to control at least a majority of territory in eleven states (out of the 34 U.S. states in February 1861), and asserted claims to two more. Both sides raised large volunteer and conscription armies. Four years of intense combat, mostly in the South, ensued.

During 1861–1862 in the war's Western Theater, the Union made significant permanent gains—though in the war's Eastern Theater the conflict was inconclusive. On January 1, 1863, Lincoln issued the Emancipation Proclamation, which made ending slavery a war goal, declaring all persons held as slaves in states in rebellion "forever free." To the west, the Union destroyed the Confederate river navy by the summer of 1862, then much of its western armies, and seized New Orleans. The successful 1863 Union siege of Vicksburg split the Confederacy in two at the Mississippi River. In 1863, Confederate General Robert E. Lee's incursion north ended at the Battle of Gettysburg. Western successes led to General Ulysses S. Grant's command of all Union armies in 1864. Inflicting an ever-tightening naval blockade of Confederate ports, the Union marshaled resources and manpower to attack the Confederacy from all directions. This led to the fall of Atlanta in 1864 to Union General William Tecumseh Sherman and his march to the sea. The last significant battles raged around the ten-month Siege of Petersburg, gateway to the Confederate capital of Richmond.

The Civil War effectively ended on April 9, 1865, when Confederate General Lee surrendered to Union General Grant at the Battle of Appomattox Court House, after Lee had abandoned Petersburg and Richmond. Confederate generals throughout the Confederate army followed suit. The conclusion of the American Civil War lacks a clean end date: land forces continued surrendering until June 23. By the end of the war, much of the South's infrastructure was destroyed, especially its railroads. The Confederacy collapsed, slavery was abolished, and four million enslaved black people were freed. The war-torn nation then entered the Reconstruction era in a partially successful attempt to rebuild the country and grant civil rights to freed slaves.

The Civil War is one of the most studied and written about episodes in the history of the United States. It remains the subject of cultural and historiographical debate. Of particular interest is the persisting myth of the Lost Cause of the Confederacy. The American Civil War was among the earliest to use industrial warfare. Railroads, the telegraph, steamships, the ironclad warship, and mass-produced weapons saw wide use. In total the war left between 620,000 and 750,000 soldiers dead, along with an undetermined number of civilian casualties. President Lincoln was assassinated just five days after Lee's surrender. The Civil War remains the deadliest military conflict in American history. The technology and brutality of the Civil War foreshadowed the coming World Wars.